Anti-Viperin Antibody, clone MaP.VIP

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一般描述

Virus inhibitory protein endoplasmic reticulum-associated interferon-inducible (Viperin) belongs to the RSAD2 family and is highly inducible by both type I and type II interferons, but little or no induction is observed in moncytic cell lines. Studies suggest that viperin is involved in host antiviral response, as viperin induction is observed from viral infections. Research also reveals that viperin inhibits influenza replication by disrupting its release from the plasmic membrane through the altering of plasma membrane fluidity by affecting formation of lipid rafts. Lipid rafts are known detergent-resistant microdomian sites for influenza budding.

免疫原

Recombinant protein corresponding to human Viperin.

应用

Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected Viperin in human colon and rat liver tissues.

Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in HepG2 cell lysate (Hinson, E., et al. (2008). JBC. 284(7):4705–4712).

Flow Cytometry Analysis: A representative lot was used by an independent laboratory in mouse liver, spleen, lung, and lymph node cells (Hinson, E., et al. (2010). J. Immunol. 184:5723-5731).

Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in mouse spleen cells (Hinson, E., et al. (2010). J. Immunol. 184:5723-5731).
Anti-Viperin Antibody, clone MaP.VIP detects level of Viperin & has been published & validated for use in WB, IH, FC, IP & IC.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

质量

Evaluated by Western Blot in mouse macrophage stimulated with IFN gamma and LPS.

Western Blot Analysis: 1 ?g/mL of this antibody detected Viperin in 10 ?g of mouse macrophage stimulated with IFN gamma and LPS.

目标描述

~42 kDa observed

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Mouse macrophage stimulated with IFN gamma and LPS

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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