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Anti-VEGFA antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB5700629
包装型号
规格纯度
价格
4713.83 *本价格含增值税费
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服务
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数量
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半岛bd体育手机客户端 名称:
Anti-VEGFA antibody produced in rabbit
MVCD1
VEGF
VEGF A
VEGFA
L VEGFA
VPF
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 111-161 of human VEGFA (NP_001165094).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 15-27
34-45
species reactivity rat, human, mouse
浓度 0.69 mg/ml
technique(s) immunofluorescence: 1:50-1:200
immunoprecipitation (IP): 1:50-1:100
western blot: 1:500-1:2000
UniProt登记号 P15692
运输 wet ice
储存温度 ?20℃
Gene Information human ... VEGFA(7422)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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