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Anti-VAPB antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1411626
规格纯度
purified immunoglobulin, buffered aqueous solution
价格
4618.16 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-VAPB antibody produced in rabbit
VAMP-B
ALS8
VAP-B
VAP-C
VAMP-C
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Vesicle-associated membrane protein-associated protein (VAPB) is encoded by the gene mapped to human chromosome 20q13.32. The encoded protein is characterized with a major sperm protein (MSP) domain and amphipathic helical structure, which might form coiled/coil protein-protein interaction motif and a hydrophobic C- terminus. VAPB is ubiquitously expressed and is localized to the intracellular membranes, such as endoplasmic reticulum (ER) and the Golgi apparatus.
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. (provided by RefSeq)

免疫原

VAPB (AAH01712, 1 a.a. ~ 243 a.a) full-length human protein.

Sequence
MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL

生化/生理作用

Vesicle-associated membrane protein-associated protein (VAPB) facilitates endoplasmic reticulum (ER)-Golgi transport and secretion. In addition, it is also involved in various processes, such as ER stress and the unfolded protein response (UPR) and bouton formation at the neuromuscular junction. VAPB acts along with protein tyrosine phosphatase-interacting protein 51 (PTPIP51) to regulate calcium homeostasis. Mutation in the gene is associated with development of various disorders, such as amyotrophic lateral sclerosis 8 (ALS8), late-onset spinal muscular atrophy finkel type.

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 26.73 kDa
species reactivity human, mouse
technique(s) western blot: 1 μg/mL
NCBI登记号 BC001712
UniProt登记号 O95292
运输 dry ice
储存温度 ?20℃
Gene Information human ... VAPB(9217)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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