Anti-UCMA antibody produced in rabbit

半岛bd体育手机客户端 说明

免疫原

UCMA antibody was raised against a 16 amino acid peptide near the carboxy terminus of human UCMA.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.

联系

The action of this antibody can be blocked using blocking peptide SBP3500050.

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	predicted mol wt 15 kDa
species reactivity	mouse, human
technique(s)	indirect ELISA: suitable western blot: suitable
NCBI登记号	NP_660357
UniProt登记号	Q8WVF2
运输	dry ice
储存温度	?20℃
Gene Information	human ... UCMA(221044)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable