半岛bd体育手机客户端 说明
一般描述
Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer’s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.
特异性
This antibody is predicted to not cross-react with TTBK2.
免疫原
KLH-conjugated linear peptide corresponding to human TTBK1.
应用
This TTBK1 antibody is validated for use in WB & IHC for the detection of the TTBK1 protein.
Immunohistochemistry Analysis: 2.5 ?g/mL of this antibody from a representative lot detected. TTBK1 in mouse brain tissue.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
质量
Evaluated by Western Blot in Jurkat cell lysate.
Western Blotting Analysis: 1 ?g/mL of this antibody detected TTBK1 in 15 ?g of Jurkat cell lysate.
目标描述
~143 kDa observed
外形
Purified rabbit polyclonal in buffer containing PBS and 0.02% sodium azide.
Antigen Affinity Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Jurkat cell lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 纯化方式 | affinity chromatography |
| species reactivity | mouse, human |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| UniProt登记号 | Q5TCY1 |
| 运输 | wet ice |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
