半岛bd体育手机客户端 说明
一般描述
TRRAP, a member of the TRA1 subfamily of the PI3/PI4 kinase family, is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. It plays a central role in MYC (c-Myc) transcription activation, and also participates in cell transformation by MYC. TRRAP is required for p53/TP53-, E2F1- and E2F4-mediated transcription activation, and is also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. It likely performs by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Although probably not required in the steps following histone acetylation in processes of transcription activation, it may be required for the mitotic checkpoint and normal cell cycle progression. It is a component of various HAT complexes, including the PCAF, TFTC, TIP60 STAGA and BAF53 complexes. The PI3K/PI4K domain of this nuclear protein is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity.
免疫原
TRRAP (Q9Y6H4, 186-221)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human TRRAP.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:50-1:100 indirect ELISA: 1:1000 |
| NCBI登记号 | NP_003487 |
| UniProt登记号 | Q9Y4A5 |
| 运输 | dry ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... TRRAP(8295) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
