Anti-Trpv4 Antibody, clone 1B2.6

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一般描述

Transient receptor potential cation channel subfamily V member 4 is a multitransmembrane non-selective cation channel encoded by the TRPV4 (also known as CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VR-OAC, VRL-2, VRL2, VROAC) gene and belong to the OSM9-like transient receptor potential channel (OTRPC) subfamily within the transient receptor potential (TRP)3 superfamily of channels. Ankyrin (ANK) repeats/domains are shown to be important for functional channel expression, and ANK domain mutations are found in patients suffering from Spinal muscular atrophies (SMA, also known as hereditary motor neuropathies) and hereditary motor and sensory neuropathies (HMSN). (PMID 16293632, 20037587, 20037588).

特异性

This antibody is expected to react to all isoforms.

免疫原

GST-tagged recombinant protein corresponding to human Trpv4.

应用

Anti-Trpv4 Antibody, clone 1B2.6 is an antibody against Trpv4 for use in Western Blotting and Immunocytochemistry.
Immunocytochemistry Analysis: 10 ?g/mL from a representative lot detected Trpv4 in NIH/3T3 cells.
Research Category
Signaling
Research Sub Category
Signaling Neuroscience

质量

Evaluated by Western Blotting in SK-MEL-28 cell lysate.

Western Blotting Analysis: 0.1 ?g/mL of this antibody detected Trpv4 in 10 ?g of SK-MEL-28 cell lysate.

目标描述

~86-98 kDa observed. Uniprot describes 6 isoforms produced by alternative splicing ranging from ~86 to 98 kDa Uncharacterized band(s) may appear in some lysates.

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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