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Anti-TREM1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1407541
规格纯度
purified immunoglobulin, buffered aqueous solution
价格
5045.46 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-TREM1 antibody produced in mouse
TREM-1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).[supplied by OMIM

免疫原

TREM1 (NP_061113.1, 1 a.a. ~ 234 a.a) full-length human protein.

Sequence
MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP

生化/生理作用

Triggering receptor expressed on myeloid cells like-1 (TREML1) associates with a transmembrane adaptor molecule called DNAX activation protein of 12kDa (DAP12). TREM1 induces calcium mobilization and triggers secretion of pro-inflammatory chemokines and cytokines.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~26.4 kDa
species reactivity human
technique(s) western blot: 1 μg/mL
NCBI登记号 NM_018643
UniProt登记号 Q9NP99
运输 dry ice
储存温度 ?20℃
Gene Information human ... TREM1(54210)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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