Anti-Transthyretin Antibody, clone 7G8-E11-E7

半岛bd体育手机客户端 说明

一般描述

Transthyretin is one of the three major thyroid hormone-binding proteins in plasma and/or cerebrospinal fluid of vertebrates. It exists mainly as a homotetrameric protein of approximately 55 kDa in plasma and, in sera and cerebrospinal fluid, is a carrier of the thyroid hormone thyroxine (T4) and retinol. While mostly known for being the transporter of thyroxine and retinol, when mutated, TTR is also well-described as the cause of familial amyloid polyneuropathy, a neurodegenerative lethal disorder characterized by systemic deposition of TTR amyloid fibrils, particularly in the peripheral nervous system. Recently, studies have shown that TTR has an important function development of peripheral and central nervous system physiology, namely by participating in behavior, in the maintenance of normal cognitive processes during ageing, amidated neuropeptide processing and nerve regeneration. Additionally, it has been proposed that TTR is neuroprotective in Alzheimer′s disease, by preventing the formation of amyloid beta fibrils (Fleming C.E. et al. (2009) Prog Neurobiol., Epub ahead of print

特异性

This antibody recognizes Transthyretin.

免疫原

Purified human Transthyretin.

应用

This Anti-Transthyretin Antibody, clone 7G8-E11-E7 is validated for use in ELISA, WB for the detection of Transthyretin.

质量

Evaluated by Western Blot in human placenta lysate.

Western Blot Analysis: 2 ?g/ml of this antibody detected Transthyretin in 10 ?g of human placenta lysate.

目标描述

Transthyretin exists mainly as a homotetrameric protein of approximately 55 kDa in plasma. A single band of ~26 kDa was observed, which is an approximate size of a dimeric component that makes up the said homotetramer.

外形

Protein G Purified
Format: Purified

分析说明

Control
Human placenta lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	7G8-E11-E7, monoclonal
species reactivity	human
technique(s)	ELISA: suitable western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_000362.1
UniProt登记号	P02766
运输	wet ice
Gene Information	human ... TTR(7276)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable