半岛bd体育手机客户端 说明
一般描述
Mouse polyclonal antibody raised against a full-length human TOM1L1 protein.
The gene TOM1L1 (target of myb1 like 1 membrane trafficking) is mapped to human chromosome 17q23.(5) The protein has a VHS (Vps27p/Hrs/Stam) domain at the N-terminal, a GAT (GGA (Golgi-localizing, ?-adaptin ear domain homology, ADP-ribosylation factor (Arf)-binding protein and Tom) domain at the center and interaction motifs at the C-terminal.1,2
免疫原
TOM1L1 (AAH29396.1, 1 a.a. ~ 346 a.a) full-length human protein.
Sequence
MAFGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSENHEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDLSPSPRMPRATLGELNTMNNQLSGLSK
生化/生理作用
TOM1L1 (target of myb1 like 1 membrane trafficking) is an adaptor protein, which is involved in vesicular trafficking as well as intracellular signaling. It negatively controls the mitogenic and transforming functions in fibroblasts by working as a substrate for SRC (tyrosine protein kinase).1,2 It is involved in EGF (epidermal growth factor)-mediated internalization of EGF receptor.4 TOM1L1 is downregulated in cutaneous squamous cell carcinoma and esophageal squamous cell carcinoma.3
外形
Solution in phosphate buffered saline, pH 7.4
基本信息
NACRES | NA.41 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
生物来源 | mouse |
偶联物 | unconjugated |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
分子量 | antigen ~38.7 kDa |
species reactivity | human |
technique(s) | western blot: 1 μg/mL |
NCBI登记号 | BC029396.1 |
UniProt登记号 | O75674 |
运输 | dry ice |
储存温度 | ?20℃ |
Gene Information | human ... TOM1L1(10040) |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich