Anti-TNFSF12 antibody produced in rabbit

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一般描述

Tumour necrosis factor superfamily member 12 (TNFSF), formerly known as TWEAK (tumor necrosis factor-like weak inducer of apoptosis) is a soluble cytokine ligand. TNFSF signals through a transmembrane protein receptor, fibroblast growth factor-inducible 14 (Fn14). In human chromosome the gene TNFSF is localized on 17p13.1.

免疫原

Synthetic peptide directed towards the N terminal region of human TNFSF12

生化/生理作用

TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. The elevated levels of TNFSF is pathologically significant in case of rheumatoid arthritis, multiple sclerosis, lupus nephritis in kidney. etc.,

序列

Synthetic peptide located within the following region: LGLLLAVVSLGSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPF

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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