半岛bd体育手机客户端 说明
一般描述
TMIGD2 (transmembrane and immunoglobulin domain-containing protein 2) is a cell adhesion protein, which has one immunoglobulin (Ig) domain in its extracellular region, one transmembrane region and a cytoplasmic domain made of 110 amino acids which is rich in proline. It is highly expressed in endothelial and epithelial cells. This gene maps to human chromosome 19q13.3, spans 10.2kb and has 5 exons. The mRNA for this gene is found mainly in lymphoid organs, with highest expression in spleen, thymus, liver and peripheral blood lymphocyte.
免疫原
Transmembrane and immunoglobulin domain-containing protein 2 precursor recombinant protein epitope signature tag (PrEST)
应用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
生化/生理作用
TMIGD2 (transmembrane and immunoglobulin domain-containing protein 2) is involved in modulating the morphology of cell, cell-cell interactions and cell migration. It increases cell-cell interaction and aggregation, along with increase in focal adhesions. It regulates angiogenesis by binding with various SH3 (SRC homology 3) domain containing proteins such as SPIN90 (SH3 protein interacting with Nck, 90kDa). SPIN90 also mediates cytoskeleton reorganization and therefore, controls cell adhesion. TMIGD2 is responsible for activation and co-stimulation of T-cells through AKT (v-Akt Murine Thymoma Viral Oncogene) pathway.
特点和优势
Prestige Antibodies?are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies?to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
联系
Corresponding Antigen APREST72192.
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC
基本信息
| 人类蛋白质图谱编号 | HPA011081 Human Protein Atlas characterization data |
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 半岛bd体育手机客户端 线 | Prestige Antibodies?Powered by Atlas Antibodies |
| 形式 | buffered aqueous glycerol solution |
| species reactivity | human |
| 包装 | antibody small pack of 25 μL |
| 增强验证 | recombinant expression Learn more aboutAntibody Enhanced Validation |
| technique(s) | immunoblotting: 0.04-0.4 μg/mL immunohistochemistry: 1:50-1:200 |
| 免疫原序列 | CQVDQATAWERLRVKWTKDGAILCQPYITNGSLSLGVCGPQGRLSWQAPSHLTLQLDPVSLNHSGAYVCWAAVEIPELEEAEGNITRLFVDPDDPTQNRNRIA |
| UniProt登记号 | Q96BF3 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... TMIGD2(126259) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
