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位置: 首页> 品牌> Sigma-Aldrich> Anti-TMEM173/STING Antibody, clone 1B1.1

Anti-TMEM173/STING Antibody, clone 1B1.1

品牌
Sigma-Aldrich
货号
MABF223
规格纯度
clone 1B1.1, from mouse
价格
5037.27 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-TMEM173/STING Antibody, clone 1B1.1
Stimulator of interferon genes protein, hSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Transmembrane protein 173
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

TMEM173/STING, also known as STING, or Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA or Transmembrane protein 173, and encoded by the gene TMEM173/ERIS/MITA/STING, is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferons. STING acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol. Upon binding STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. STING also mediates cell death signaling via the activation of the ERK pathway. STING is found in multiple intracellular locations including the endoplasmic reticulum, plasma cell membrane, mitochondrion outer membrane, and perinuclear regions. STING is expressed in the B-cell lineage both immature and mature B cells but not plasma cells. Mutations in STING cause defects in innate immunity and compromised immune health.

免疫原

GST-tagged recombinant protein corresponding to human TMEM173/STING.

应用

Anti-TMEM173/STING Antibody, clone 1B1.1 | MABF223 is an antibody against TMEM173/STING Antibody for use in Western Blotting.

质量

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected TMEM173/STING in 10 ?g of Jurkat cell lysate.

目标描述

~37 kDa observed

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified antibody
antibody product type primary antibodies
克隆 1B1.1, monoclonal
species reactivity human
technique(s) western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_938023
UniProt登记号 Q86WV6
运输 wet ice
Gene Information human ... TMEM173(340061)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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