Anti-Thrombospondin-2 Antibody

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一般描述

Thrombospondins (TSPs) are a family of homotrimeric multi-domain glycoproteins involved in modulation of cell adhesion, proliferation, and migration and have been implicated clinically in the development of atherosclerosis, angiogenesis, and oncogenesis. TSP2, a member of the thrombospondin family is a secreted protein, but is present only transiently in extracellular matrix and is rapidly internalized for degradation by fibroblasts after binding to the cell surface. It also interacts with matrix metalloproteinases (MMPs) and matrix serine proteases, such as plasminogen activator. TSP2 is reportedly controls the apoptosis-proliferation balance in endothelial cells. Although TSP2 is a potent inhibitor of angiogenesis, its N-terminal region exhibits pro-angiogenic activities mediated by beta 1 integrins. Loss of TSP2 expression is associated with local invasive behavior, tumor neovascularization, and metastasis. Decreased TSP2 expression has been correlated with malignant progression and angiogenesis in some cancers. TSP2 levels are also highly expressed in developing and healing tissues.

特异性

This antibody recognizes the Laminin G-like region of Thrombospondin-2.
Other homologies: Mouse, Rat, and Bovine (93% sequence homology).

免疫原

KLH-conjugated linear peptide corresponding to the Laminin G-like region of human Thrombospondin-2.
Epitope: Laminin G-like region

应用

Anti-Thrombospondin-2 Antibody is an antibody against Thrombospondin-2 for use in Western Blotting.

质量

Evaluated by Western Blot in concentrated conditioned media from MG-63 cells.

Western Blot Analysis: 0.25 µg/mL of this antibody detected Thrombospondin-2 in 10 µg of concentrated conditioned media from MG-63 cells.

目标描述

~180 kDa observed. The calculated molecular weight is 130 kDa, however Thrombospondin-2 has been shown to have bands at ~135 kDa and ~180 kDa in western blots (Streit, M., et al. (1999). PNAS. 96(26):14888-14893).

外形

Affinity purified

分析说明

Control
Concentrated conditioned media from MG-63 cells

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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