Anti-Thorase Antibody, clone 9G7.1

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一般描述

Thorase is an ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Thorase thus helps mediate synaptic plasticity and learning and memory. Thorase expression is required for NMDA-stimulated AMPAR internalization and for the inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane as both of these require ATP processing by Thorase. Thorase is vital for keeping in balance the molecular construction-deconstruction cycle that is required for memory formation. Thorase is one of many AAA+ ATPases that drive the assembly of proteins needed to form specialized receptors at the surfaces of synapses. These receptors are stimulated by neighboring neurons, setting up the signaling and answering connections vital to brain function. Thorase regulates the all-important complementary process of receptor disassembly at synapses, which ultimately tamps down signaling. Thorase is a postsynaptic localized protein, and also is associated with the peroxisome and cell junctions and synapses. Thorase is expressed in the brain and testis primarily.

免疫原

GST-tagged recombinant protein corresponding to human Thorase.

应用

This Anti-Thorase Antibody, clone 9G7.1 is validated for use in Western Blotting for the detection of Thorase.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Thorase in 10 µg of human brain tissue lysate.

质量

Evaluated by Western Blotting in human lymph node tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Thorase in 10 µg of human lymph node tissue lysate.

目标描述

~41 kDa observed

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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