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位置: 首页> 品牌> Sigma-Aldrich> Anti-Tensin 3 antibody, Mouse monoclonal

Anti-Tensin 3 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200416
规格纯度
clone TN-17, purified from hybridoma cell culture
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Tensin 3 antibody, Mouse monoclonal
Monoclonal Anti-TEM6
Monoclonal Anti-TNS3
Monoclonal Anti-TENS1
Monoclonal Anti-Tensin 3 antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-Tensin 3 (mouse IgG1 isotype) is derived from the hybridoma TN-17 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to an internal sequence of human Tensin 3. Tensins are multidomain proteins that are characterized with homologous C1, protein phosphatases (PTPases) , C2, Src homology 2 (SH2) domains and pTyr-binding (PTB) domains.
Tensin 3 (TNS3) is encoded by the gene mapped to human chromosome 7p12.3. TNS3 transcript is expressed at high level in thyroid and at moderate level in placenta. In addition, the protein is also expressed at minimal levels in brain, heart, lung, liver, pancreas, kidney, skeletal muscle, white blood cells and prostate. TNS3 is a member of tensin protein family.

免疫原

synthetic peptide corresponding to an internal sequence of human Tensin 3, conjugated to KLH. The isotype is determined using a double diffusion immunoassay using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

应用

Monoclonal Anti-Tensin 3 antibody produced in mouse has been used in western blotting.
Monoclonal Anti-Tensin 3 antibody produced in mouse has also been used in immunofluorescence.

生化/生理作用

Tensin 3 (TNS3) plays a vital role in stimulation of epidermal growth factor (EGF) signaling pathway. The encoded protein supports fundamental role of thyroid hormone in normal thyroid tissues. Decreased expression of the gene leads to development of human renal cell carcinoma (RCC).
Tensin 3 facilitates cell migration and tumorigenesis in cell lines from advanced lung cancer, breast cancer and melanoma. In these cell lines, The protein is phosphorylated by Src in its SH2 domain, leading to tumorigenesis and metastasis, implicating tensin 3 as an oncoprotein regulated by Src.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 TN-17, monoclonal
形式 buffered aqueous solution
分子量 antigen ~170 kDa
species reactivity human
浓度 ~1.0 mg/mL
technique(s) indirect immunofluorescence: 2.5-5.0 μg/mL using PC3 cells.
western blot: 0.5-1.0 μg/mL using extracts of SW-620 cells.
同位素/亚型 IgG1
UniProt登记号 Q68CZ2
运输 dry ice
储存温度 ?20℃
Gene Information human ... TNS3(64759)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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