您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anti-Tau, a.a. 210-241 Antibody, clone Tau-5

Anti-Tau, a.a. 210-241 Antibody, clone Tau-5

品牌
Sigma-Aldrich
货号
MABN162
规格纯度
clone TAU-5, from mouse
价格
6190.47 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-Tau, a.a. 210-241 Antibody, clone Tau-5
Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Tau is a neuronal protein implicated in several neurodegenerative disorders, among which Alzheimer’s disease, Picks’s disease, and frontotemporal dementia are most widely studied. Tau interacts extensively with the cytoskeleton via its microtubule-binding domain and is involved in the assembly and stabilization of microtubules. Tau also contains proline rich domains and multiple phoshorylation sites which are targeted by a wide variety of kinases including JNK, MAPK, GSK3, PKA, PKC, and CAMKII. In disease conditions, Tau is hyperphosphorylated and insoluble and occurs mainly in the form of toxic neurofibrillary tangles that destabilizes the cytoskeleton, and disrupts axonal transport and intracellular signaling networks. Neurodegeneration resulting from accumulation of defective tau proteins is marked by a range of cognitive deficits, among other debilitating symptoms.

免疫原

Purified bovine Tau

应用

Detect Tau, a.a. 210-241, clone Tau-5 using this Anti-Tau, a.a. 210-241 Antibody, clone Tau-5 validated for use in Western Blotting.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

质量

Purified by Western Blot in rat cortex tissue lysate.

Western Blot Analysis: 0.1 ?g/mL of this antibody recognized Tau in 10 ?g of rat cortex tissue lysate.

目标描述

~48 kDa observed. This antibody is expected to recognize all phosphorylated and nonphosphorylated isoforms of Tau at molecular weights of ~45-68 kDa

联系

Replaces: MABN361; 577801

外形

Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives.
Protein G Purified

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

分析说明

Control
Rat cortex tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 TAU-5, monoclonal
species reactivity human, rat
species reactivity (predicted by homology) bovine (immunogen homology)
technique(s) western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_776531.1
UniProt登记号 P29172
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map