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位置: 首页> 品牌> Sigma-Aldrich> Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1

Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1

品牌
Sigma-Aldrich
货号
MABN349
规格纯度
clone 1B12.1, 0.5 mg/mL, from mouse
价格
5520.38 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1
Synaptotagmin-12, Synaptotagmin XII, SytXII, Synaptotagmin-12 (SYT12)
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Synaptotagmin-12 (SYT12) , also known as Synaptotagmin-12, Synaptotagmin XII, SytXII, and encoded by the gene SYT12, is an important protein involved in calcium dependent exocytosis of secretory vesicles through calcium and phospholipid binding to the C2 domain and Synaptotagmin-12 may serve as calcium sensors in the process of vesicular trafficking and exocytosis. Synaptotagmin-12 is a synaptic vesicle phosophoprotein that modulates spontaneous neurotransmitter release, but unlike other family members Synaptotagmin-12 differs from classical synaptotagmins in that it does not bind Ca(2+). In synaptic vesicles, synaptotagmin-12 forms a complex with synaptotagmin-1 that prevents synaptotagmin-1 from interacting with SNARE complexes. Synaptotagmin-12 also is an abundant synaptic vesicle protein that is important in LTP transmission. For instance, its phosphorylation by cAMP Protein Kinase is necessary for hippocampal mossy fiber LTP.

免疫原

GST-tagged recombinant protein corresponding to the cytoplasmic domain of human Synaptotagmin-12 (SYT12).
Epitope: Cytoplasmic domain

应用

Research Category
Neuroscience
This Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1 is validated for use in Western Blotting for the detection of Synaptotagmin-12 (SYT12).
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected Synaptotagmin-12 (SYT12) in 200 ?g of rat brain tissue lysate.

目标描述

~ 47 kDa observed

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 1B12.1, monoclonal
species reactivity human, rat
浓度 0.5 mg/mL
technique(s) western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_001171351
UniProt登记号 Q8IV01
运输 wet ice
Gene Information human ... SYT12(91683)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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