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Anti-SUN1 Antibody

品牌
Sigma-Aldrich
货号
ABT273
规格纯度
from rabbit, purified by affinity chromatography
价格
5520.38 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-SUN1 Antibody
SUN domain-containing protein 1, Protein unc-84 homolog A, Sad1/unc-84 protein-like 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

SUN domain-containing protein 1 (SUN1), also known as Protein unc-84 homolog A or Sad1/unc-84 protein like 1 (UNC84A), is a component of the SUN-protein-containing complexes also called LINC (linker of nucleoskeleton and cytoskeleton) complexes. These complexes link the nucleoskeleton and cytoskeleton structures together in a scaffold like fashion. SUN1 is required for interkinetic nuclear migration and nucleokinesis as well as nucleus-centrosome coupling during radial neuronal migration and glial migration in the cortex. SUN1 also is important during meiosis and is required for proper gametogenesis as well. Additionally, SUN1 it is important in the distribution of nuclear pore complexes on the nuclear membrane. Interestingly, LINC complexes are also critical for vital functions such as hearing. For instance, recent research demonstrates that the position of the nucleus in sensory epithelial cells, partly governed by SUN1, appears critical for normal hearing.

免疫原

Epitope: Perinuclear space domain
MBP-tagged recombinant protein corresponding to the perinuclear space domain of human SUN1.

应用

Research Category
Cell Structure
Detect SUN1 using this Anti-SUN1 antibody validated for use in western blotting & ICC.
Western Blotting Analysis: A 1:1;000 dilution from a representative lot detected SUN1 in 10 ?g of HepG2, Jurkat, and PC3 cell lysate.
Western Blotting Analysis: A representative lot detected SUN1 recombinant protein (Haque, F., et al. (2010). Journal of Biol. Chem. 285(5): 3487-3498).
Immunocytochemistry Analysis: A representative lot detected SUN1 in human foreskin fibroblasts cells (Haque, F., et al. (2010). Journal of Biol. Chem. 285(5): 3487-3498).
Research Sub Category
Adhesion (CAMs)

质量

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: A 1:1;000 dilution of this antibody detected SUN1 in 10 ?g of A431 cell lysate.

目标描述

~ 110 kDa observed. The calculated molecular weight is 90 kDa, however Sun1 has been shown as a ~80-110 kDa band in western blots (Gob, E., et al. (2011). Commun. Integr Biol. 4(4):440-442). Uncharacterized band(s) may appear in some lysates.

外形

Affinity purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human, rat
technique(s) immunocytochemistry: suitable
western blot: suitable
NCBI登记号 NP_001124437
UniProt登记号 O94901
运输 wet ice
Gene Information human ... SUN1(23353)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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