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位置: 首页> 品牌> Sigma-Aldrich> Anti-SUMO4 (N-term) antibody produced in rabbit

Anti-SUMO4 (N-term) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300168
规格纯度
saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-SUMO4 (N-term) antibody produced in rabbit
Anti-Small ubiquitin-like modifier 4
Anti-SUMO-4
Anti-SMT3 suppressor of mif two 3 homolog 2
Anti-SMT3H4
Anti-Small ubiquitin-like protein 4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins′ subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes. This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the N-term region of human SUMO4.

免疫原

SUMO4 (NP_001002255, 1-30)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide at the N-term region of human SUMO4.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 saturated ammonium sulfate (SAS) precipitated
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity human
technique(s) indirect ELISA: 1:1000
NCBI登记号 NP_001002255
UniProt登记号 Q6EEV6
运输 dry ice
储存温度 ?20℃
Gene Information human ... SUMO4(387082)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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