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位置: 首页> 品牌> Sigma-Aldrich> Anti-Sulf-2 Antibody, clone 2B4

Anti-Sulf-2 Antibody, clone 2B4

品牌
Sigma-Aldrich
货号
MABC584
规格纯度
clone 2B4, from mouse
价格
6022.61 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Sulf-2 Antibody, clone 2B4
Extracellular sulfatase Sulf-2, hSulf-2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Sulf-2 is also important in neurological situations including myelination and glial cell differentiation and GDNF activity. Sulf-2 activity is also found in the kidney and important in glomerular basement membrane development and glomerular function. Finally, Sulf-2 is involved in heparan sulfate metabolism. Sulf-2 removes sulfate moieties on heparan sulfate proteoglycans which in turn modulate the heparin binding growth factor signaling activity of the cell. Sulf-2 also impacts extracellular matrix interactions and it is important during development and growth, as well as Wnt signaling and VEGF production by endothelial cells during vascularization. In disease, Sulf-2 expression in cancer is upregulated and inhibition of Sulf-2 limits cancer progression and showed increased apoptosis within tumors, thus Sulf-2 activation is being examined as a potential anti-cancer therapy.

应用

Western Blot Analysis: 1 ?g/mL from a representative lot of this antibody detected Sulf-2 in transfected HEK293 cell lysates (Data courtesy of Dr. Mark Singer).

Western Blot Analysis: A representative lot of this antibody detected Sulf-2 in transfected HEK293 cell lysates, but not in non-transfected HEK293 cell lysates (Lemjabbar-Alaoui, H., et al., (2010) Oncogene 29:635–646).

Immunohistochemistry Analysis: A representative lot of this antibody detected Sulf-2 in Human lung and squamouse cell carcinoma tissue (Lemjabbar-Alaoui, H., et al., (2010) Oncogene 29:635–646).

ELISA: A representative lot of this antibody detected Sulf-2, but not Sulf-1 by ELISA (Lemjabbar-Alaoui, H., et al., (2010) Oncogene 29:635–646).
This Anti-Sulf-2 Antibody, clone 2B4 is validated for use in Western Blotting and Immunohistochemistry and ELISA for the detection of Sulf-2.

质量

Evaluated by Western Blotting in A549 cell lysate.

Western Blotting Analysis: 2 ?g/mL of this antibody detected Sulf-2 in 10 ?g of A549 cell lysate.

目标描述

~125 & 50 kDa observed.
Sulf-2 is synthesized as a ~125 kDa pre-protein and is subsequently cleaved into ~75 kDa and ~50 kDa fragments, which are held together by disulfide bonds in the mature protein.

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 2B4, monoclonal
species reactivity human
technique(s) ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型 IgG1κ
NCBI登记号 NP_001155313
UniProt登记号 Q8IWU5
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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