Anti-SQSTM1 Antibody, clone 20F1.1

半岛bd体育手机客户端 说明

一般描述

Ubiquitin-binding protein p62, also known as Sequestosome-1 (SQSTM1), is a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-κB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-κB in response to upstream signals. Defects in p62/SQSTM1 are a cause of Paget disease of bone (PDB), a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts

免疫原

GST-tagged recombinant protein corresponding to human SQSTM1.

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SQSTM1 in human thalamus and human cerebellum tissue.
Research Category
Neuroscience
Anti-SQSTM1 Antibody, clone 20F1.1 is a highly specific mouse monoclonal antibody, that targets p62 & has been tested in western blotting & IHC.
Research Sub Category
Developmental Signaling

质量

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected SQSTM1 in 10 ?g of rat brain tissue lysate.

目标描述

~60 kDa observed

外形

Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Rat brain tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified antibody
antibody product type	primary antibodies
克隆	20F1.1, monoclonal
species reactivity	human, rat
technique(s)	immunohistochemistry: suitable western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_001135770
UniProt登记号	Q13501
运输	wet ice
Gene Information	human ... SQSTM1(8878)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable