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位置: 首页> 品牌> Sigma-Aldrich> Anti-SPG11 antibody produced in rabbit

Anti-SPG11 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB3500003
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-SPG11 antibody produced in rabbit
Anti-Colorectal carcinoma-associated protein
Anti-Spastic paraplegia 11
Anti-Spatacsin
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

免疫原

SPG11 antibody was raised against a 15 amino acid peptide of human SPG11.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage. It is expressed in all structures of the brain, with a high expression in the cerebellum. SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene. Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.

联系

The action of this antibody can be blocked using blocking peptide SBP3500003.

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
species reactivity human, rat, mouse
technique(s) immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号 AAI53880
UniProt登记号 Q96JI7
运输 dry ice
储存温度 ?20℃
Gene Information human ... SPG11(80208)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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