Anti-Sonic Hedgehog (Shh) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE). It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

免疫原

A synthesized peptide derived from human Sonic Hedgehog (Shh) (Shh)

外形

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
antibody product type	primary antibodies
克隆	monoclonal
形式	liquid
species reactivity	rat, mouse, human
浓度	0.45 mg/mL
technique(s)	immunohistochemistry: 1:50-1:200 western blot: 1:500-1:2000
UniProt登记号	Q15465
运输	wet ice
储存温度	?20℃
Gene Information	human ... SHH(6469)

安全信息

闪点(F)	Not applicable
闪点(C)	Not applicable