Anti-Snurportin 1 (N-terminal) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Snurportin 1 (also known as RNA U transporter 1, SPN1 and SNUPN) comprises three known functional domains: an N-terminal importin-β binding domain (IBB) motif and trimethylguanosine (TMG) cap-binding domain. SNUPN is mapped to human chromosome 15q24.2.

特异性

Anti-Snurportin 1 (N-terminal) recognizes human snurportin 1.

应用

Anti-Snurportin 1 (N-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

生化/生理作用

Snurportin 1 (also known as RNA U transporter 1, SPN1 and SNUPN), mediates nuclear import of 7-methylguanosine (m⁷G) and trimethylguanosine (TMG)-capped uridine-rich small nuclear RNPs (U snRNPs), an important step in the maturation of the spliceosome. The N-terminal importin-β binding domain (IBB) motif, which binds importin β that mediates the interaction with the nuclear pore complex (NPC). The TMG cap-binding domain interacts specifically with m³G-cap but not with m⁷G-cap structures, and an ill-defined region responsible for binding to exportin 1. The active nuclear import, entry of spliceosomal U snRNPs into the nucleus by the importin b/Snurportin1/U snRNP complex does not require RanGTP. Snurportin 1 accumulates in Cajal bodies after import of U2 but not U1 snRNPs.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

Store at –20 ℃. For continuous use, the product may be stored at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots at –20 ℃. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen ~41 kDa
包装	antibody small pack of 25 μL
浓度	~1.0 mg/mL
technique(s)	immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human Snurportin 1 western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human Snurportin 1
运输	dry ice
储存温度	?20℃
Gene Information	human ... SNUPN(10073)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable