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Anti-SND1 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200504
规格纯度
clone SND1-3, purified from hybridoma cell culture
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-SND1 antibody, Mouse monoclonal
Monoclonal Anti-TDRD11
Monoclonal Anti-staphylococcal nuclease and tudor domain containing 1, p100
Monoclonal Anti-SND1 antibody produced in mouse
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-SND1 (mouse IgG1 isotype) is derived from the hybridoma SND1-3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. The Staphylococcal nuclease and tudor domain containing 1 (SND1) protein is highly conserved from yeast to human. It contains five repeated staphylococcal nuclease-like domains and a tudor-like domain, probably required for its interaction with nucleic acids and proteins, respectively. The SND1 protein is a constituent of the RNA-induced silencing complex (RISC). The SND1 gene is mapped to the human chromosome location 7q31.3.

特异性

Monoclonal Anti-SND1 recognizes human, mouse, rat, hamster and bovine SND1.

免疫原

Synthetic peptide corresponding to an internal region of human SND1, conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and rat SND1.

应用

Monoclonal Anti-SND1 antibody produced in mouse may be used in:

  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

生化/生理作用

The Staphylococcal nuclease and tudor domain containing 1 (SND1) protein is involved in the regulation of transcription. It also modulates the RNA interference (RNAi) function, RNA splicing, editing and stability. The SND1 protein promotes the degradation of hyper-edited inosine containing miRNA precursors. It modulates miRNA processing and expression through RNA editing by adenosine deaminase acting on RNA (ADAR). SND1 is up-regulated in human colon cancer, breast cancer and cancer cell lines. This protein promotes nucleic acid interaction along with protein-protein interactions. It also interacts with transcription factors as a transcriptional co-activator of Epstein-Barr virus nuclear antigen 2 (EBNA2) and signal transducer and activator of transcription (STAT5 and STAT6).

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

储存及稳定性

For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze at -20oC in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 SND1-3, monoclonal
形式 buffered aqueous solution
分子量 antigen ~102 kDa
species reactivity mouse, human, rat
浓度 ~1.0 mg/mL
technique(s) western blot: 1-2 μg/mL using whole extracts of human HeLa or HEK-293T cells.
同位素/亚型 IgG1
UniProt登记号 Q7KZF4
运输 dry ice
储存温度 ?20℃
Gene Information human ... SND1(27044)
mouse ... Snd1(56463)
rat ... Snd1(64635)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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