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Anti-SMAD7 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200345
规格纯度
~1.0 mg/mL, affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-SMAD7 antibody produced in rabbit
Anti-MADH8
Anti-SMAD family member 7
Smad7 Antibody
SMAD7 Antibody-Anti-SMAD7 antibody produced in rabbit
Anti-MADH7
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

SMAD7 (mothers against decapentaplegic homolog 7) is a Tbx1 (T-box 1) interacting gene and is encoded by the gene mapped to human chromosome 18q21.1.

免疫原

peptide corresponding to an internal region of human SMAD7, conjugated to KLH. The corresponding sequence is identical in monkey, mouse, rat and bovine

应用

Anti-SMAD7 has been used in western blot analysis and immunofluorescence.

生化/生理作用

SMAD7 (mothers against decapentaplegic homolog 7) is a modulator of TGFβ (transforming growth factorβ) signaling in immune cells which are associated with ulcerative colitis and inflammatory bowel syndrome. It plays a major role in the etiology of CRC (colorectal cancer). In addition, it also acts as a mediator of the negative feedback loop for both the TGFβ and BMP (bone morphogenetic proteins) signaling pathways. It is essential for the remodelling of pharyngeal artery and the enlargement of great vessel. In mouse, homozygous removal of Smad7 causes primarily fourth-related arch artery defects. Silencing of Smad7 in RCD (refractory coeliac disease) biopsy samples can decrease the expression of interleukin-6 and tumour necrosis factor-α. Polymorphism of this gene is associated with colorectal cancer. SMAD7 is an inhibitor of the TGFβ (transforming growth factor beta) /BMP (bone morphogenetic proteins) pathway.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

人类蛋白质图谱编号 HPA028897 Human Protein Atlas characterization data
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~46 kDa
species reactivity mouse, monkey, bovine, rat, human
浓度 ~1.0 mg/mL
technique(s) indirect immunofluorescence: 5-10 μg/mL using human A549 cells.
western blot: 2-4 μg/mL using whole extracts of HEK-293 cells over-expressing human SMAD7
UniProt登记号 O15105
运输 dry ice
储存温度 ?20℃
Gene Information human ... SMAD7(4092)
mouse ... Smad7(17131)
rat ... Smad7(81516)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1

Sigma-Aldrich

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