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ANTI-SMAD6 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1412513
规格纯度
clone 4F3, purified immunoglobulin, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
ANTI-SMAD6 antibody produced in mouse
HsT17432
SMAD6
MADH7
MADH6
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The protein encoded by this gene belongs to the SMAD family of proteins, which are related toDrosophila‘ mothers against decapentaplegic ′ (Mad) andC. elegansSma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.
SMAD family member 6 (SMAD6) is encoded by the gene mapped to human chromosome 15q22.31. The encoded protein is localized in both nuclei and cytoplasm and is expressed in variety of human tissues, including ovary. SMAD6 consists of MAD homology 2 (MH2) domain involved in protein-protein interaction.

免疫原

SMAD6 (NP_005576, 285 a.a. ~ 384 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
RDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTR

生化/生理作用

SMAD family member 6 (SMAD6) induces endocytosis and negatively regulates apoptosis by inhibiting transforming growth factor-β (TGF-β) signaling pathway. In addition, it also indirectly regulates stemness by inhibiting erythropoiesis in cord blood hematopoietic stem cells (HSCs). Mutation in the gene leads to congenital cardiovascular malformation (CVM). Elevated expression/genetic variation of SMAD6 is associated with the development of ovarian cancer.

外形

Solution in phosphate buffered saline, pH 7.4

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 4F3, monoclonal
形式 buffered aqueous solution
分子量 antigen 36.74 kDa
species reactivity human
technique(s) immunohistochemistry: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型 IgG2bκ
NCBI登记号 NM_005585
UniProt登记号 O43541
运输 dry ice
储存温度 ?20℃
Gene Information human ... SMAD6(4091)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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