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Anti-SMAD7 (N-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200346
规格纯度
~1.0 mg/mL, affinity isolated antibody, suitable for western blot: 2 μg/mL
价格
6575.35 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-SMAD7 (N-terminal) antibody produced in rabbit
Anti-MADH8
Anti-Mothers against DPP homolog 8
Anti-CRCS3
Anti-MAD homolog 7
Anti-MAD homolog 8
Anti-SMAD
Anti-MADH7
Anti-Mothers against DPP homolog 7
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

SMAD7 (mothers against decapentaplegic homolog 7) is a Tbx1 (T-box 1) interacting gene and is encoded by the gene mapped to human chromosome 18q21.1.
SMAD7 (mothers against decapentaplegic homolog 7), that binds the E3 ubiquitin ligase Smurf1/2. SMAD7 belongs to the family of inhibitory Smads (I-Smads).

免疫原

peptide corresponding to the N-terminal region of human SMAD7, conjugated to KLH. The corresponding sequence is identical in monkey and differs by 2 amino acids in mouse and rat.

应用

Anti-SMAD7 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

生化/生理作用

SMAD7 (mothers against decapentaplegic homolog 7) is a modulator of TGFβ (transforming growth factor β) signaling in immune cells which are associated with ulcerative colitis and inflammatory bowel syndrome. It plays a major role in the etiology of CRC (colorectal cancer). In addition, it also acts as a mediator of the negative feedback loop for both the TGFβ and BMP (bone morphogenetic proteins) signaling pathways. It is essential for the remodelling of pharyngeal artery and the enlargement of great vessel. In mouse, homozygous removal of Smad7 causes primarily fourth-related arch artery defects. Silencing of Smad7 in RCD (refractory coeliac disease) biopsy samples can decrease the expression of interleukin-6 and tumour necrosis factor-α. Polymorphism of this gene is associated with colorectal cancer. SMAD7 is an inhibitor of the TGFβ (transforming growth factor beta) /BMP (bone morphogenetic proteins) pathway.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~46 kDa
species reactivity human
浓度 ~1.0 mg/mL
technique(s) indirect immunofluorescence: 1-2 μg/mL using human A549 cells.
western blot: 2-4 μg/mL using whole extracts of HEK-293 cells over-expressing human SMAD7.
UniProt登记号 O15105
运输 dry ice
储存温度 ?20℃
Gene Information human ... SMAD7(4092)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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