您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anti-SMAD6 (N-terminal) antibody produced in rabbit

Anti-SMAD6 (N-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200384
规格纯度
~1.0 mg/mL, affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-SMAD6 (N-terminal) antibody produced in rabbit
Anti-MADH6
Anti-SMAD family member 6
Anti-MADH7
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

SMAD6 is a member of inhibitory Smads (I-Smad) family. It consists of two conserved domains, the N-terminal MH1 and C-terminal MH2, that are separated by a proline-rich linker region of varying length.

免疫原

peptide corresponding to the N-terminal region of human SMAD6, conjugated to KLH. The corresponding sequence is identical in rat and differs by a single amino acid in mouse.

应用

Anti-SMAD6 (N-terminal) antibody produced in rabbit has been used in:

  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

生化/生理作用

SMAD6 plays an important role in transforming growth factor-β (TGF-β) pathway. It regulates cell proliferation, apoptosis and differentiation. SMAD6 is a key negative regulator of bone morphogenetic protein (BMP) signaling in the cytoplasm and in the nucleus. SMAD6 inhibits SMAD signaling in the nucleus by interacting with transcriptional repressors such as HOXC-8, class I histone deacetylases (HDACs) and transcriptional corepressor C-terminal binding protein (CtBp).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~60 kDa
species reactivity human, mouse
浓度 ~1.0 mg/mL
technique(s) immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over-expressing human SMAD6
indirect immunofluorescence: 5-10 μg/mL using mouse 3T3 cells
western blot: 1-2 μg/mL using whole extracts of HEK-293T cells over-expressing human SMAD6
UniProt登记号 O43541
运输 dry ice
储存温度 ?20℃
Gene Information human ... SMAD6(4091)
rat ... Smad6(367100)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map