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位置: 首页> 品牌> Sigma-Aldrich> Anti-SLFN11 Antibody, clone 4G9

Anti-SLFN11 Antibody, clone 4G9

品牌
Sigma-Aldrich
货号
MABF248
规格纯度
clone 4G9, 0.25 mg/mL, from mouse
价格
5016.79 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-SLFN11 Antibody, clone 4G9
Schlafen family member 11, SLFN11
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

SLFN11, also known as Schlafen family member 11, and encoded by the gene SLFN11, is an interesting protein that is part of our innate defense against retroviruses. The protein is induced by interferon and acts to inhibit the translation of retrovirus specific proteins. SLFN11 also plays a role in cell cycle arrest and apoptosis induction, particularly in response to DNA damage. SLFN11 is localized to the nucleus and is widely expressed and up regulated in various cancers including ovarian and adenocarcinomas, and recent work suggests that SLFN11 may behave as a biomarker for prediction of response to DNA-damaging agents in the clinical setting.

免疫原

Recombinant protein corresponding to human SLFN11.

应用

Anti-SLFN11 Antibody, clone 4G9 is an antibody against SLFN11 for use in western blotting & IP.
Western Blotting/Immunoprecipitation Analysis: A representative lot immunoprecipitated SLFN11 from transfected HEK293 cell lysates. The same lot was used to detect SLFN11 in Western Blotting (Prof. Michael David, University of California, San Diego.).

Electron Mobility Shift Assay Analysis: A representative lot from an independent laboratory detected SLFN11 bound t-RNA (Li, M., et al. (2012). Nature. 491(7422):125-128.).
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

质量

Evaluated by Western Blotting in HEK293T cell lysates transfected with SLFN11 or a negative control.

Western Blotting Analysis: A 1:500 dilution of this antibody detected SFN11 in HEK293T cell lysates transfected with SLFN11 and not in HEK293T cell lysates transfected with a negative control.

目标描述

~100 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

外形

Purified by Ion-Exchange Chromatography
Format: Purified
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 4G9, monoclonal
species reactivity human
浓度 0.25 mg/mL
technique(s) immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型 IgMκ
NCBI登记号 NP_001098057
UniProt登记号 Q7Z7L1
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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