Anti-SESN1 antibody produced in mouse

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一般描述

Sestrin 1 (SESN1) is expressed in the nucleus and is a target gene of the tumor suppressor p53. The gene encoding it is localized on human chromosome 6q21.

免疫原

SESN1 (NP_055269.1, 1 a.a. ~ 551 a.a) full-length human protein.

Sequence
MAEGENEVRWDGLCSRDSTTRETALENIRQTILRKTEYLRSVKETPHRPSDGLSNTESSDGLNKLLAHLLMLSKRCPFKDVREKSEFILKSIQELGIRIPRPLGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKTQHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQKLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTFGCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEALMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTSYGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMAMHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTKRMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT

生化/生理作用

Sestrin 1 (SESN1) activates AMP-responsive protein kinase (AMPK) which phosphorylates tuberous sclerosis complex 2 (TSC2), and subsequently inhibits mammalian target of rapamycin protein (mTOR). Mutations in the gene encoding the protein have been linked to heterotaxia.

外形

Solution in phosphate buffered saline, pH 7.4

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