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位置: 首页> 品牌> Sigma-Aldrich> Anti-Sav1 (C-terminal) antibody produced in rabbit

Anti-Sav1 (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB2109101
规格纯度
affinity isolated antibody
价格
5258.35 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-Sav1 (C-terminal) antibody produced in rabbit
WWP3
SAV
WW45
1700040G09Rik
WWP4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

免疫原

Synthetic peptide directed towards the C-terminal region of Sav1

序列

Synthetic peptide located within the following region: PCAPSVPRYDQPPPITYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARA

外形

Supplied at 0.5 mg/ml in phosphate-buffered saline, 0.09% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 42 kDa
species reactivity (predicted by homology) rabbit, pig, bovine, canine, horse, mouse, rat, human
浓度 0.5 mg/mL
technique(s) western blot: 1 μg/mL
NCBI登记号 NM_022028
运输 wet ice
储存温度 ?20℃
Gene Information human ... SAV1(60485)

安全信息

储存分类代码 10 - Combustible liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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