Anti-S100-A10 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

S100 calcium binding protein A10 (S100-A10), also known as calpactin I light chain or p11 or cellular ligand of annexin II, is a member of the S100 family of proteins. S100-A10 is mapped to human chromosome 1q21.3 and is expressed in the intestine, lungs and kidney. It contains two EF-hand calcium-binding motifs.

特异性

Anti-S100-A10 recognizes human S100-A10.

免疫原

synthetic peptide corresponding to a sequence at the N-terminus of human S100-A10, conjugated to KLH

应用

Anti-S100-A10 antibody produced in rabbit may be used in immunoblotting and immunohistochemistry.

生化/生理作用

S100 calcium binding protein A10 (S100-A10) functions as the regulatory subunit of Annexin II (ANX2) to generate the active heterotetramer ANX2/p11 (ANX2T). S100-A10 is implicated in prostate cancer and multiple myeloma and enables cells to reach adhesion and growth at the bone marrow microenvironment. Elevated levels of S100-A10 are observed in squamous non-cell lung cancer, anaplastic large cell lymphoma, renal cell carcinoma and pediatric intracranial ependymoma. Experimental evidence implicates S100-A10 involvement in the mechanism of action of antidepressant drugs and electroconvulsive seizures due to its interaction with specific serotonin receptors.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

Store at –20 ℃. For continuous use, store at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses,in vitrodiagnostic uses,ex vivoorin vivotherapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
抗体形式	IgG fraction of antiserum
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	~11 kDa
species reactivity	human
technique(s)	immunoblotting: 1:500-1:1000 using human epidermoid carcinoma A431 cell line extract immunohistochemistry: 1:500-1:1000 using heat-retrieved formalin-fixed, paraffin-embedded Human Pancrease carcinoma sections
UniProt登记号	P60903
运输	dry ice
储存温度	?20℃
Gene Information	human ... S100A10(6281)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable