Anti-RUNX1 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

The antibody detects endogenous level of total AML1(RUNX1) protein.
Runt-related transcription factor 1 (RUNX1) is a transcription factor that plays a vitral role in hematopoiesis, osteogenesis and neurogenesis. It is a member of Runt-related transcription factors (RUNXs). It was first identified as a component of Polyomavirus enhancer binding protein 2 (PEBP2) and Moloney murine leukemia virus enhancer core binding factor (CBF). Three isoforms of the protein have been identified: RUNX1a, RUNX1b and RUNX1c.

免疫原

Peptide sequence around aa. 6-10 (D-A-S-T-S), according to the protein NP_001116079.1

应用

Anti-RUNX1 antibody produced in rabbit is suitable for western blot at a working dilution of 1:500-1:1000.

生化/生理作用

RUNX1 (Runt-related transcription factor 1) plays a vital role in tumour suppression and oncogenic activities. In hematopoiesis, it is involed in hematopoietic development, hematopoietic stem cell homeostasis, and various blood malignancies. It may have clinicopathological impact on the proliferation of human bone marrow cells used in transplantation therapy.

特点和优势

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目标描述

CBF binds to the core site, 5′-PYGPYGGT-3′, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	~55 kDa
species reactivity	human
浓度	1 mg/mL
technique(s)	western blot: 1:500-1:1000
同位素/亚型	IgG
免疫原序列	(D-A-S-T-S)
NCBI登记号	NM_001122607.1
UniProt登记号	Q01196
运输	wet ice
储存温度	?20℃
Gene Information	human ... RUNX1(861)

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable