半岛bd体育手机客户端 说明
一般描述
Ras-related protein Rab-7A (Rab7A, RAB7) is a small intracellular protein typically associated with cytoplasmic vesicles, phagosomes, and endosomes and is expressed in most cells but particularly high in muscle. It plays an important role in regulating the endo-lysosomal trafficking of proteins as well as in the endosomal trapping of pathogens and viruses. Besides endosome-lysosome trafficking, Rab7A functions in a variety of other critical cellular processes including nutrient uptake, growth factor mediated growth, neurotrophin transport, lipid transport, lysosome and phagosome maturation and development, as well as pathogen and virus innate immunity functions. RAB7A interacts with a number of other proteins within the cell, some important in endosome trafficking like RILP (Rab-interacting lysosomal protein) and CHM (Rab escort protein 1) others like RAC1 have a more pleiotropic impact and are part of many cellular processes, including the cell cycle, cell-cell adhesion, cytoskeletal motility, and cellular differentiation.
免疫原
GST-tagged recombinant protein corresponding to human Rab7A.
应用
Detect Rab7A using this Anti-Rab7A antibody, clone 5G8.1 validated for use in western blotting & IHC.
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Rab7A in human breast cancer and human cardiac myocytes and lymphocytes in human heart tissue.
质量
Evaluated by Western Blotting in SK-MEL28 cell lysate.
Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Rab7A in 10 ?g of SK-MEL28 cell lysate.
目标描述
~23 kDa observed
外形
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 5G8.1, monoclonal |
| species reactivity | human |
| 浓度 | 0.5 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| 同位素/亚型 | IgG2bκ |
| NCBI登记号 | NP_004628 |
| UniProt登记号 | P51149 |
| 运输 | wet ice |
| Gene Information | human ... RAB7A(7879) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
