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位置: 首页> 品牌> Sigma-Aldrich> Anti-PTP1B Antibody (Oxidized), clone scFvs 45

Anti-PTP1B Antibody (Oxidized), clone scFvs 45

品牌
Sigma-Aldrich
货号
MABS456
规格纯度
clone scFvs 45, from chicken
价格
5352.52 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-PTP1B Antibody (Oxidized), clone scFvs 45
Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

PTP1B is the prototypic member of the protein tyrosine phosphatase (PTP) family, which comprises at least 37 proteins. The family is characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. The PTPs have high substrate specificity for phosphotyrosyl proteins. At the primary sequence level, PTPs share little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP1B is a negative regulator of insulin and leptin signal transduction and may be a potential therapeutic target for diabetes and obesity. Insulin also influences the expression of splice variants of PTP1B.

特异性

This antibody only reacts with the oxidized form.

免疫原

Recombinant protein corresponding to the PTP1B-OX of human PTP1B (Oxidized).
Epitope: PTP1B-OX

应用

Research Category
Signaling
Research Sub Category
Signaling Neuroscience
Immunoprecipitation Analysis: This antibody immunoprecipitated PTP1B (Oxidized) recombinant (aa 1-321; WT and CASA mutant) (Haque, A., et al. (2011). Cell. 147:185-198).
Immunoprecipitation Analysis: This antibody immunoprecipitated PTP1B (Oxidized) recombinant (aa 1-321; WT and CASA mutant) (Haque, A., et al. (2012). Nature America. 7(12):2127-2143).
Inhibits Activity/Function Analysis: A representative lot detected PTP1B (Oxidized) in recombinant PTP1B (aa 1-321; WT and CASA mutant) and scFv45) (Haque, A., et al. (2011). Cell. 147:185-198).
Inhibits Activity/Function Analysis: A representative lot detected PTP1B (Oxidized) in recombinant PTP1B (aa 1-321; WT and CASA mutant)and scFv45) (Haque, A., et al. (2012). Nature America. 7(12):2127-2143).
Anti-PTP1B Antibody (Oxidized), clone scFvs 45 | MABS456 is an antibody against PTP1B Antibody for use in Immunoprecipitation, Inhibits Activity/Function.

质量

Evaluated by Immunoprecipitation in recombinant PTP1B (aa 1-321; WT and CASA mutant) and scFv45 cell lysate.

Immunoprecipitation Analysis: 278 ng of this antibody detected PTP1B (Oxidized) in recombinant PTP1B (aa 1-321; WT and CASA mutant) and scFv45 cell lysate.

目标描述

~37 kDa observed. The calculated molecular weight is 50kDa however PTP1B has been observed at ~37 kDa since it is a truncated form (aa 1-321). Uncharacterized band(s) may appear in some lysates.

联系

Replaces: 04-1140

外形

Format: Purified
Purified chicken monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Ni-NTA agarose

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 chicken
质量水平 100
抗体形式 purified antibody
antibody product type primary antibodies
克隆 scFvs 45, monoclonal
species reactivity human
technique(s) immunoprecipitation (IP): suitable
NCBI登记号 NP_002818
UniProt登记号 P18031
运输 wet ice
Gene Information human ... PTPN1(5770)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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