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位置: 首页> 品牌> Sigma-Aldrich> Anti-PTK2B (Ab-402) antibody produced in rabbit

Anti-PTK2B (Ab-402) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300468
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-PTK2B (Ab-402) antibody produced in rabbit
Anti-FAK2 antibody produced in rabbit
Anti-FADK2 antibody produced in rabbit
Anti-PTK2B protein tyrosine kinase 2 beta antibody produced in rabbit
Anti-CADTK antibody produced in rabbit
Anti-CAKB antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

PTK2B/ Pyk2 (proline-rich tyrosine kinase 2β) is a non receptor protein kinase that belongs to the focal adhesion kinase family. It is also known as FAK2 (focal adhesion kinase 2), RAFTK (related adhesion focal tyrosine kinase) and CAKB (cell adhesion kinase beta). Its expression is confined to the endothelium, central nervous system and hematopoietic lineages. It is located on human chromosome 8p21.1.

免疫原

Peptide sequence around aa. 400-404 (D-I-Y-A-E), according to the protein PTK2B.

应用

Anti-PTK2B (Ab-402) antibody has been used in immunohistofluorescence.

生化/生理作用

Protein tyrosine kinase 2 β (PTK2B) participates in the pathogenesis of Alzheimer′s disease (AD). It induces tumor progression in multiple myeloma. It helps in the multiplication, movement and survival of cells.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01634069
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~116 kDa
species reactivity mouse, human, rat
浓度 1 mg/mL
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同位素/亚型 IgG
免疫原序列 (D-I-Y-A-E)
NCBI登记号 NP_004094.3
UniProt登记号 Q14289
运输 wet ice
储存温度 ?20℃
Gene Information human ... PTK2B(2185)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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