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位置: 首页> 品牌> Sigma-Aldrich> Anti-PTEN (Ab-380/382/383) antibody produced in rabbit

Anti-PTEN (Ab-380/382/383) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300336
规格纯度
affinity isolated antibody
价格
5095.34 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-PTEN (Ab-380/382/383) antibody produced in rabbit
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半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

免疫原

Peptide sequence around aa. 378-382/380-384/381-385 (R-Y-S-D-T-T-D-S), according to the protein PTEN.

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Western Blotting (1 paper)

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~54 kDa
species reactivity rat, mouse, human
浓度 1 mg/mL
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
同位素/亚型 IgG
免疫原序列 (R-Y-S-D-T-T-D-S)
NCBI登记号 NP_000305.3
UniProt登记号 P60484
运输 wet ice
储存温度 ?20℃
Gene Information human ... PTEN(5728)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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