Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody

半岛bd体育手机客户端 说明

一般描述

Protein capicua homolog (CIC) , also known as Capicua Transcriptional Repressor, Capicua Homolog, and encoded by the gene CIC, is a transcriptional repressor which plays a role in development of the central nervous system (CNS). CIC is a new subfamily of the HMG-box superfamily and the gene′s expression is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS, and thus the gene is implicated in CNS development, in particular in granule cell development. CIC appears to be central to cerebellar development and ErbB signaling as well. Recent research has demonstrated that CIC is highly expressed in certain cancers including medulloblastomas, but also the loss of expression may serve as a biomarker for other cancer types such as oligodendrogliomas.

免疫原

GST-tagged recombinant protein corresponding to human Protein capicua homolog (CIC).

应用

Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected Protein capicua homolog (CIC) in human cerebral cortex, rat olfactory bulb, and rat cerebral cortex tissue.
Research Category
Neuroscience
This Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of Protein capicua homolog (CIC).
Research Sub Category
Developmental Signaling

质量

Evaluated by Immunohistochemistry in rat cerebellum tissue.

Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Protein capicua homolog (CIC) in rat cerebellum tissue.

目标描述

164 kDa calculated

外形

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	6E12.1, monoclonal
species reactivity	human, rat
浓度	1 mg/mL
technique(s)	immunohistochemistry: suitable (paraffin)
同位素/亚型	IgG1κ
NCBI登记号	NP_055940
UniProt登记号	Q96RK0
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable