Anti-PRDM16 Antibody

半岛bd体育手机客户端 说明

一般描述

PR domain zinc finger protein 16 (PRDM16) is also called Transcription factor MEL1 (MDS1/EVI1-like gene 1). PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. PRDM16 is expressed in the uterus and kidney. PRDM16 regulates transcription through DNA binding and plays a role in the differentiation of myoblastic precursors into brown adipose tissue (BAT), and represses TGF-beta signalling. Translocations in PRDM16 occur in subsets of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) cases.

免疫原

KLH-conjugated linear peptide corresponding to human PRDM16.

应用

Immunoprecipitation Analysis: 10 ?g from a representative lot immunoprecipitated PRDM16 from 500 ?g of K562 nuclear extract.

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected PRDM16 in human kidney tissues.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Detect PRDM16 using this rabbit polyclonal antibody, Anti-PRDM16 Antibody validated for use in western blotting, IP & IHC.

质量

Evaluated by Western Blotting in LNCaP nuclear extract.

Western Blotting Analysis: 2 ?g/mL of this antibody detected PRDM16 in 10 ?g of LNCaP nuclear extract.

目标描述

~140 kDa observed. Four isoforms are known to exist. This protein has been observed at 150 kDa, 135 kDa, and 100 kDa (EMD Millipore Cat. No. ABD130). Uncharacterized band(s) may be observed in some cell lysates.

外形

Purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	human
species reactivity (predicted by homology)	bovine (based on 100% sequence homology), nonhuman primates (based on 100% sequence homology), canine (based on 100% sequence homology), horse (based on 100% sequence homology), guinea pig (based on 100% sequence homology)
technique(s)	immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable
NCBI登记号	NP_071397
UniProt登记号	Q9HAZ2
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable