Anti-Podoplanin Antibody, clone NZ1.2

半岛bd体育手机客户端 说明

一般描述

Human podoplanin (T1alpha-2, aggrus and gp36) is a 38 kDa type-1 transmembrane glycoprotein that consists of 162 amino acids, nine of which form the intracellular domain. The highly O-glycosylated extracellular domain contains a sialic acid that is linked to an alpha-2,3 galactose, which forms the main part of the protein’s carbohydrate moieties. It is expressed in a select variety of human tissues and organs, and is also found in lymphatic, but not blood vessel endothelium. While its mode of action remains unclear, podoplanin is suggested to play a critical role in several physiological processes and conditions such as cell migration, cytoskeleton organization, tissue development, and tissue repair, as well as in carcinogenesis and tumor cell invasion.

特异性

This antibody detects Podoplanin at the PLAG domain.

免疫原

Epitope: PLAG Domain
Protein sequence corresponding to the PLAG domain of human Podoplanin.

应用

Anti-Podoplanin Antibody, clone NZ1.2 is an antibody against Podoplanin for use in WB, IH.
Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Podoplanin in human lung adenocarcinoma and colorectal tissue.
Research Category
Apoptosis & Cancer
Research Sub Category
Cytoskeleton

质量

Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected Podoplanin in 10 ?g of human lung tissue lysate.

目标描述

~25 kDa observed.
4 isoforms are produced by alternative splicing, at molecular weights of ~17 kDa (isoform 1), ~18 kDa (isoform 2), ~25 kDa (isoform 3), and ~25 kDa (isoform 4).

外形

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human lung tissue lysate.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	rat
抗体形式	purified antibody
antibody product type	primary antibodies
克隆	NZ1.2, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_001006625
UniProt登记号	Q86YL7
运输	wet ice
Gene Information	human ... PDPN(10630)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable