Anti-PMP22 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

Peripheral myelin protein 22 (PMP22), also called as growth arrest-specific protein 3 (GAS-3), is a tetraspan glycoprotein, encoded by the gene mapped to human chromosome 17p12–13. PMP22 is highly expressed in myelin-forming Schwann cells of peripheral nerves.
Anti-PMP22 Antibody detects endogenous levels of total PMP22 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human PMP22.

Immunogen Range:111-160

应用

Anti-PMP22 antibody produced in rabbit has been used in:

• immunofluorescence
• western blotting
• immunohistochemistry

Anti-PMP22, C-Terminal antibody produced in rabbit has been used in immunofluorescence analysis.

生化/生理作用

Peripheral myelin protein 22 (PMP22) plays a vital role in myelination during development of peripheral nerve, cell–cell interactions, cell proliferation, maintenance of axons and the determination of myelin thickness and stability. Biological function of PMP22, might include formation and or maintenance of intercellular junctions and possibly of tight junctions (TJs). Aberrations, duplications or mutations in PMP22 gene lead to majority of heritable demyelinating peripheral neuropathies, such as Charcot-Marie-tooth disease type IA (CMT1A) and Dejerine-Sottas syndrome. PMP2, might be involved in regulation of Schwann cell proliferation and differentiation.5 Overexpression of PMP22 might contribute to the development of chronic myeloid leukemia (CML). PMP22 might, thus, act as a therapeutic target for the treatment of CML.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous glycerol solution
分子量	17 kDa
species reactivity	rat, human, mouse
浓度	~1 mg/mL
technique(s)	ELISA: 1:40000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000
NCBI登记号	Q01453
UniProt登记号	Q01453
运输	wet ice
储存温度	?20℃
Gene Information	human ... PMP22(5376)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable