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Anti-PLSCR1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1406267
规格纯度
purified immunoglobulin, buffered aqueous solution
价格
5045.46 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-PLSCR1 antibody produced in mouse
MMTRA1B
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Phospholipid scramblase 1 (PLSCR1) is a 35kDa calcium dependant phospholipid translocator. The gene is located on human chromosome 3q24. The protein is overexpressed in tumor cells.

免疫原

PLSCR1 (NP_066928.1, 1 a.a. ~ 318 a.a) full-length human protein.

Sequence
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW

生化/生理作用

Phospholipid scramblase 1 (PLSCR1) bidirectionally transfers lipids across the membranes. It negatively regulates autophagy in mantle cell lymphoma (MCL). This protein is known to scramble phospholipids in the plasma membrane and thereby, disrupt membrane asymmetry. It functions as a multifunctional signalling molecule. It also has nuclease activity. PLSCR1 plays a role in cell proliferation, differentiation, apoptosis, pathogenesis of cancers, particularly leukemia.

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~35 kDa
species reactivity human
technique(s) western blot: 1 μg/mL
NCBI登记号 NM_021105.1
UniProt登记号 O15162
运输 dry ice
储存温度 ?20℃
Gene Information human ... PLSCR1(5359)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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