您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anti-PKC ζ antibody produced in rabbit

Anti-PKC ζ antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4502380
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-PKC ζ antibody produced in rabbit
KPCZ
Protein kinase C ζ type
PKC2
PRKCZ
PKC-ζ
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Protein kinase C (PKC) ? is an isoenzyme, which belongs to the atypical class of protein kinase C family. PKC? is encoded by the gene mapped to human chromosome 1p36.33-p36.2. PKC ? is expressed in human eosinophils. This protein is characterized with a PB1 (Phox and Bem1) domain in the N-terminal, a pseudosubstrate (PS) sequence, a C1 domain (or phorbol esters/diacylglycerol binding domain) of a single Cys-rich zinc-finger motif, and a kinase domain in the C-terminal.

免疫原

The antiserum was produced against synthesized peptide derived from human PKC zeta.

Immunogen Range:526-575

应用

Anti-PKC ?, C-Terminal antibody produced in rabbit has been used in immunohistochemistry.

生化/生理作用

Isoenzymes of protein kinase C (PKC) family play a vital role in downstream signaling and cell functions. PKC ? regulates adhesion and effector functions of human eosinophils stimulated with platelet-activating factor (PAF) or complement (C) 5a. PKC ? and PKC δ might act as a therapeutic target for decreasing eosinophilic inflammation in clinical conditions such as asthma. PKC ? is calcium–independent, and is activated by phospholipids including phosphatidic acid (PA), phosphatidylinositol triphosphates and ceramides. Experimental studies state that, PKC ? is involved in the mitogen-activated protein kinase (MAPK) cascade, transcriptional factor NF-κB (NF-κB) activation, ribosomal S6-protein kinase signaling, and cell polarity. PKC-? mediates hypoxia-induced Na,K-ATPase endocytosis in the alveolar epithelial cells (AEC).4 PKC-? functions as a potential biomarker for human prostate cancer.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 67 kDa
species reactivity rat, human, mouse
浓度 ~1 mg/mL
technique(s) ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号 Q05513
UniProt登记号 Q05513
运输 wet ice
储存温度 ?20℃
Gene Information human ... PRKCZ(5590)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map