Anti-PITX3 Antibody, clone 12G4.1

半岛bd体育手机客户端 说明

一般描述

Pituitary homeobox 3 (UniProt O75364; also known as Homeobox protein PITX3, Paired-like homeodomain transcription factor 3) is encoded by the PITX3 (also known as ASMD, CTPP4, CTRCT11, PTX3) gene (Gene ID 5309) in human. PITX3 is a bicoid-related homeodomain transcription factor critical for the development of the ocular lens, mesencephalic dopaminergic neurons and skeletal muscle. PITX3 exerts its developmental impact on dopaminergic neurons by directly regulating the expression of a cascade of downstream genes, including TH, VMAT2, DAT, BDNF, and GDNF. PITX3 and the related PITX2 are both key regulators of intracellular redox state and play an important role in preventing DNA damage during fetal myogenesis. Human PITX3 gene mutations are linked to cataracts and anterior segment abnormalities and PITX3 polymorphisms are associated with Parkinson′s disease. In aphakia (ak) mice, deletions in the Pitx3 promoter region cause abnormal lens development.

免疫原

KLH-conjugated linear peptide corresponding to a sequence within the N-terminal region of human PITX3.

应用

Anti-PITX3 Antibody, clone 12G4.1 is an antibody against PITX3 for use in Western Blotting.

质量

Evaluated by Western Blotting in human retinoblastoma Y79 cell lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected PITX3 in 10 ?g of human retinoblastoma Y79 cell lysate.

目标描述

~32 kDa observed. Uncharacterized band(s) may appear in some lysates.

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	12G4.1, monoclonal
species reactivity	human
technique(s)	western blot: suitable
同位素/亚型	IgG2aκ
NCBI登记号	NP_005020
UniProt登记号	O75364
运输	wet ice
Gene Information	human ... PITX3(5309)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable