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位置:首页 > 品牌 > Sigma-Aldrich > Anti-Phosphatidylinositol-4-phosphate 5-kinase type-1 α

Anti-PIP5K1A (N-term) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB1300120
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
5045.46 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
半岛bd体育手机客户端 名称:
Anti-PIP5K1A (N-term) antibody produced in rabbit
Anti-Phosphatidylinositol-4-phosphate 5-kinase type-1 α
Anti-PIP5KIα
68 kDa type I phosphatidylinositol-4-phosphate 5-kinase α
Anti-PtdIns(4)P-5-kinase α
Phosphatidylinositol-4-phosphate 5-kinase type I α
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppresses apoptosis, whereas a kinase-deficient mutant does not. Protection by the wild-type PIP5KIalpha isaccompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP. Protection is not mediated through PIP3 or Akt activation. An anti-apoptotic role for PIP(2) is substantiated by the finding that PIP5KIalpha is cleaved by caspase 3 during apoptosis, and cleavage inactivates PIP5KIalpha in vitro. Mutation of the P(4) position (D279A) of the PIP5KIalpha caspase 3 cleavage consensus prevents cleavage in vitro, and during apoptosis in vivo. Significantly, the caspase 3-resistant PIP5KIalpha mutant is more effective in suppressing apoptosis than the wild-type kinase. PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and PIP5KIalpha inactivation contributes to the progression of apoptosis.

免疫原

PIP5K1A (NP_003548, 24-60)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PIP5K1A.

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

半岛bd体育手机客户端 性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI登记号NP_003548
UniProt登记号Q99755
运输dry ice
储存温度−20℃
Gene Informationhuman ... PIP5K1A(8394)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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