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位置: 首页> 品牌> Sigma-Aldrich> Anti-phospho-VE-Cadherin (pTyr731) antibody produced in rabbit

Anti-phospho-VE-Cadherin (pTyr731) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4504676
规格纯度
affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho-VE-Cadherin (pTyr 731) antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cadherin 5 (CDH5) is encoded by the gene mapped to long arm of human chromosome 16. The encoded protein is expressed in endothelial cells, but it is absent in normal epithelium.

免疫原

The antiserum was produced against synthesized peptide derived from human VE-Cadherin around the phosphorylation site of Tyr731.

Immunogen Range:697-746

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

生化/生理作用

Cadherin 5 (CDH5) plays an essential role in various cellular processes, such as regulation of cell adhesion, cell proliferation, cell survival, cell shape, cell motility, modulation of signaling pathways and transcriptional gene regulation. Cdh5/VE(vascular endothelial)-cadherin is a core component of endothelial adherens junction, which plays a vital role in angiogenic sprouting by enhancing cell migration and cell elongation. CDH5 expressed in glioblastoma multiforme (GBM), facilitates the transdifferentiation of glioblastoma stem-like cells (GSCs) to endothelial cells and to form blood vessels, under hypoxia condition. VE-cadherin induces endothelial cell-cell adhesion at adherens junctions (AJs). CDH5 gene knockout results in loss of cell polarity and modification in vascular lumenal structure. CDH5 inhibits the synthesis of CDH2 (also known as N-cadherin) in the endothelium.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 87 kDa
species reactivity human, rat, mouse
浓度 ~1 mg/mL
technique(s) ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号 P33151
UniProt登记号 P33151
运输 wet ice
储存温度 ?20℃
Gene Information human ... CDH5(1003)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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