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Anti-phospho-TDP-43 (pSer410) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200224
规格纯度
~1.0 mg/mL, affinity isolated antibody
价格
5045.46 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-phospho-TDP-43 (pSer 410) antibody produced in rabbit
Anti-phospho-ALS10
Anti-phospho-TARDBP
Anti-phospho-TARDP43
Anti-phospho-TAR DNA binding protein 43
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

TDP-43 (TAR DNA binding protein) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs), that binds single stranded RNA. TDP-43 has been implicated in the transcription regulation of HIV. TDP-43 is the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype FTLD-U and amyotrophic lateral sclerosis (ALS). TDP-43 is predominantly localized to the nucleus.

免疫原

synthetic peptide containing phosphorylated Ser410 of human TDP-43, conjugated to KLH. The corresponding sequence is identical in mouse TDP-43.

应用

Anti-phospho-TDP-43 (pSer410) antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites. Several pathogenic TDP-43 mutations have been identified in familial amyotrophic lateral sclerosis (ALS).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~43 kDa
species reactivity mouse, human
浓度 ~1.0 mg/mL
technique(s) western blot: 1-2 μg/mL using HepG2 and NIH3T3 cell lysates
UniProt登记号 Q13148
运输 dry ice
储存温度 ?20℃
Gene Information human ... TARDBP(23435)
mouse ... Tardbp(230908)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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