Anti-Phospho-RPA2-T21 antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

免疫原

A phospho specific peptide corresponding to residues surrounding T21 of human RPA2

外形

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
antibody product type	primary antibodies
克隆	monoclonal
形式	liquid
species reactivity	human, rat
浓度	0.43 mg/mL
technique(s)	western blot: 1:500-1:2000
UniProt登记号	P15927
运输	wet ice
储存温度	?20℃
Gene Information	human ... RPA2(6118)

安全信息

闪点(F)	Not applicable
闪点(C)	Not applicable